NME1 was discovered because it has a reduced mRNA transcript level in highly metastatic cells. Nucleoside diphosphate kinase is a hexamer that contains 'A' and 'B (encoded in this gene). In aggressive neuroblastomas, mutations in this gene were identified. This gene has been affected by two transcript variants that encode different isoforms.
NME/NM23 nucleoside diphosphate kinase kinase1 (NME1), an endoplasmic reticulum-associated SET-complex component that contains pp32 (GzmA), and pp32 substrates. This gene encodes this protein and is found on chromosome 17q22. You can know more about anti-NM23A/NME1 antibody RP1090 via the internet.
NME/NM23 nucleoside phosphate kinase 1- (NME1) plays a major role in tumor metastasis suppression. It binds and nicks the nuclease-hypersensitive element (NHE) of the c-myc promoter, recognizes the S1 nuclease-hypersensitive region (5'-SHS silencer) and the NHE basal promoter of platelet-derived growth factor a polypeptide (PDGF-A) as substrates for DNA nicking.
It activates to nick DNA and translocates from the endoplasmic reticulum to the nucleus. This initiates single-stranded damage. The NDK/NME/NM23 family of kinases (encoded in the gene) contains at least eight distinct proteins with different cellular localization. This group is capable of inhibiting metastasis in many types of tumor cells.
All NDK/NME/NM23 proteins have nucleoside phosphatase kinase activity (NDK). They catalyze the phosphorylation nucleoside diphosphate to the corresponding nucleoside Triphosphate, which regulates a variety of cellular events.